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The structure of the PolIIIα-clamp-exonuclease-τc complex on the other hand has remained elusive due to its dynamic nature that forms a significant hurdle for structure determination.
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Of course, business school can also be a significant hurdle for passionate founders.
This represents a significant hurdle to developing Chinese medicine as a form of evidence-based healthcare.
A significant hurdle in the initial phase of the SEACO establishment was in the recruitment of the population, to ensure as high a response rate as possible.
In many places where growth has outstripped supplies, that is becoming a significant hurdle.
"But you will have to overcome a significant hurdle in going down that route".
Raising funds to finance projects with a novel technology will therefore be a significant hurdle for Trident.
A dispute among plaintiffs has been a significant hurdle to settlement talks, people close to the discussions said.
Cost can be a significant hurdle in deploying indoor positioning systems based on infrared or radio-frequency technology.
But they are confronting a significant hurdle: their poor foreign-language skills, in particular a lack of English.
–The cost of streaming royalties also is a significant hurdle.
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CEO of Professional Science Editing for Scientists @ prosciediting.com