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STING forms a membrane trafficking system that mediates the dynamic translocation of STING and leads to the effective induction of innate immune responses (Saitoh et al., 2010), but the interaction between PLpro-TM and STING prohibits the membrane trafficking of STING, which results in inhibition of phosphorylation and dimerization of IRF3 and blocks IFN signaling transduction (Fig. 6B).
PA-LF complexes are endocytosed and trafficked to acidic vesicles, where PA forms a membrane pore and translocates LF into the cytosol [18].
Protein p7 is classified neither as a structural nor as a non-structural protein, is located in the cell ER, and forms a membrane pore.
In association with other complement proteins, C6, C7 and C8, its proteolytic fragment C5b forms a membrane attack complex to carry out cell lysis of pathogens [ 50].
GLTP also forms a membrane targeting motif that differs from those used by other important peripheral proteins, i.e., C1, C2, PH, FYVE, and PX domains.
As a positive control to confirm assay function, liposomes were also incubated with melittin bee venom peptide, which forms a membrane pore that mediates high-level dye-release [11,12].
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In summary, the data presented suggest that BAPKO_0422 forms a membrane-spanning β-barrel.
The IL-6 receptor has two forms: a membrane-bound form and a soluble form.
CX3CL1/fractalkine, a unique CX3C chemokine, exists in two forms: a membrane-bound form and a soluble form [ 9- 11].
Fst forms a membrane-binding α-helix in the N-terminal part and contains an intrinsically disordered region near the C-terminus.
The HA1 subunit forms a membrane-distal globular head that contains the receptor-binding site (RBS) and most of the antigenic regions recognized by neutralizing Abs [ 46– 46].
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