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Interestingly, the pro-apoptotic role of these variants might be relevant neither to the transamidating activity nor to the guanine nucleotide binding capacity, but to the fact that they render TG2 more prone to an aggregate forming conformation [29].
It has been suggested that the pore is generated by a transformation of membrane proteins with other 'normal' functions into a pore forming configuration – a favoured candidate has been the adenine nucleotide translocase (ANT), as this protein can undergo a Ca2+ dependent switch to a pore forming conformation, and pore opening is modulated by drugs which bind to the ANT.
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Furthermore, dynamic free-state ensembles have repeatedly been observed to contain transiently formed conformations that partially or completely resemble bound states.
Hydrophobic collapse of preformed local structure elements leads to transiently formed conformations with varying degrees of compaction (for example, molten globules, compact conformations with distinct packing of side chains).
Our results suggest that the sequence of the middle three nucleotides in the context of a star site also contributes to the energy barrier in forming this conformation.
Lim and Garber derived rules based on conformational analysis that predict which triplets can assume an A-form conformation as single-stranded RNA [ 16].
For all conformational variables, probabilities of forming native conformations were calculated by using clusters with near native centroids, as referenced to the NMR structure of TC5b.
In the disadvantageous geometry for porphyrin dimer formation on the duplex, the porphyrins induced the DNA duplex structures to the Z-form conformation.
The 2.2 angstrom resolution crystal structure of Staphylococcus aureus IleRS complexed with tRNAIle and Mupirocin shows the acceptor strand of the tRNAIle in the continuously stacked, A-form conformation with the 3′ terminal nucleotide in the editing active site.
We report here the crystal structure of HsdS from Thermoanaerobacter tengcongensis in an open form conformation at 1.95 Å resolution.
By displacing Mg2+ closer to the −1 backbone phosphate group, dione binding promotes cleavage and may favour 'relaxation' of the G-DNA into the B-form conformation.
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