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Solid tumors can hijack these formidable pathways to construct a microenvironment highly unfavorable to anti-tumor T lymphocytes able to recognize them, one of mechanisms for their immune evasion.
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Both pathways present formidable challenges, however, starting from scratch presents additional PBL unrelated challenges.
To engineer the C4 pathway into rice is therefore a formidable challenge.
THE Pathway of the Gods is a formidable name for a hiking trail, even in the picture-postcard landscape along the Amalfi Coast of Italy.
We believe that the highly specific HEs are likely to provide a more viable pathway to ultimate clinical use, although formidable challenges remain in retargeting them toward HIV sequences.
Identifying which bacteria are critical and which are bystanders, which strains affect which behaviors, by which pathways, in whom and when, is a formidable task.
Because the cost and occupancy of high conductivity materials are the elements of major concern, searching for a better design of high conductivity pathways embedded into a heat generating body is a formidable challenge.
Therefore, seeking for more efficient designs of high conductivity pathways ('inserts'), embedded into a heat generating body constitutes a formidable challenge.
Some fans grumbled as the always-formidable lines to get in the sprawling venue seemed even worse this year, and layout changes made some pathways feel like crowded back-alleys.
Achieving biological realism here is a formidable task, but could lead to a better understanding of the homeostatic and adaptive behaviours of the pathway.
The formidable threat.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com