Combination of the C2′-sulfone with a methyl group at N3 enhanced potency by nearly two orders of magnitude relative to 22, yielding BAY 85-8501 (29, HNE IC50: 65 p m) with a formidable lipophilic binding efficiency (LipE 7.2).
Projected performance requirements are leading to formidable cost and energy efficiency challenges.
From the environmental and sustainability analysis results, the unfired clay material has shown energy-efficiency and suggests a formidable economical alternative to the firing of clay building components.
In February this year, Li Keqian, who is likely to become prime minister in 2012, outlined a formidable list of tests ahead, from increasing energy efficiency to distributing wealth more equally.
Two recent reviews have dealt with the formidable problem of identification of drugs with improved efficiency and cancer selectivity (Benson et al, 2006; Collins and Workman, 2006).
The aquaporins are not "an intelligent being" in any real sense, yet they are so formidable selective that they could easily parallel Maxwell demon's efficiency in creating the right conditions for the cell.
Dendrite growth, volume change and high reactivity are the formidable challenges in terms of good cycling performance and high Coulombic efficiency as well as an expected safety guarantee of Na metal anode for the practical application.
Their encyclopedic knowledge of dance music, years spent in, around and outside of the Detroit scene, and efficiency as creators and performers has made them a formidable addition to the electronic music world.
One former senior school official described the task of replacing several or more bus companies as formidable, but said it might reduce costs and increase the system's efficiency.
Multi-ion-responsive probes are particularly attractive due to their high detection efficiencies and potential cost reductions, while there still remains the formidable challenge of discriminating different metal ions in pure aqueous media.
