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Moreover, it should be noted that even a compromised BBB remains a very formidable diffusion barrier (Palmieri et al, 2006).
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The exact mechanism is not known, but we speculate that the inhibition of mucin glycosylation may reduce the formidable mucin O-glycosylation mesh, facilitate the diffusion of drugs across the compromised mucus layer, improve intracellular drug uptake and enhance cytotoxic drug action.
The British were optimistic about gaseous diffusion, but it was clear that both gaseous and centrifugal methods faced formidable technical obstacles.
One is diffusion.
The formidable threat.
Technology diffusion?
The United States uses gaseous diffusion.
The design screams diffusion line.
It's diffusion by defusion.
They become formidable competitors.
Williamson described how he works on four ready-to-wear collections a year, each overlapping the next – it's a formidable workload, particularly when you take into account that since it was founded in 1997 the Matthew Williamson label has diversified and developed, namely with the recently launched MW diffusion line, a successful online store and retail outlets worldwide.
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