Exact(2)
A salt bridge between E179 (E195 of ALDH2) and R40 (E53 of ALDH2) moves the carboxylate group of the former away from the 2′-phosphate of the NADP+, thus avoiding steric clashes and/or electrostatic repulsion between the two groups.
It is noteworthy that, in the MelC2/MelD2 phylogenetic tree, the evolutionary distances of the MelD2s are significantly longer than those of the MelC2s, indicating divergent evolution of the former away from the latter (see also below).
Similar(56)
The economic downturn and corruption scandals have turned many former supporters away.
Sturridge and Suarez combined neatly just now to send the former racing away from Evans and into the box.
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Mr. Straw struck back today, insisting that he had the powers to turn the former hostages away if they were not granted asylum.
She found it in a remote, rural corner of southern New Jersey, and tossed her former life away to become a farmer.
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Those hurt the most by the crisis appear to be small, family-owned stores where a combination of geography and the proximity of competing stations has driven large numbers of former patrons away.
The Spaniard was speaking after his side's 1-0 defeatoto his former club away at Bayern Munich in a friendly, his first game in charge of the English club.
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