Sentence examples for formation trail from inspiring English sources

However, several studies have demonstrated that even in tumors expressing caspase-8 and all other components essential for DISC formation, TRAIL monotherapy is inefficient, probably due to high survival rates of tumor cells in response to this treatment.

That depletion of uPA alters the DISC composition by reducing the recruitment of antiapoptotic DcR2 suggests a cross-talk between uPA signaling and the formation of TRAIL receptor complexes.

The c-FLIP protumoral effect is achieved by binding c-FLIP to the death receptors through DEDs (in a ligand-dependent or ligand-independent pattern), followed by inhibition of DISC formation by TRAIL and CD95/Fas/APO1 [ 49] and consequent blockage of the proapoptotic activity of caspase-8 and caspase-10, through inhibition of their activation [ 51].

Noteworthy, MSC.sTRAILDR4 exerted augmented apoptosis-inducing activity on HCT.shDR5, as no TRAIL-R2 could impede the formation of TRAIL-R1 homotrimers, resulting in more efficient apoptosis induction by the TRAIL-R1-specific variant.

Natural animal trails from a variety of species are well documented, primarily through casual mention in the literature, but little quantitative information on the impacts of animal trails in natural environments exists [ 3, 9] Trampling, which leads to the formation of trails, is one of the most influential geomorphologic effects of large mammals such as feral horses [ 3].

In this context, Gilks and Hague [13] extended the active walker model to address the formation of trails on gradients.

Llobera and Sluckin [14] have shown that the formation of trails with zigzag patterns corresponds to an optimization strategy that involves not only the minimization of energy (by passing from less steep gradients) but also the direction of pedestrian movement.

The instantaneous as well as the time-averaged flow field suggests the formation of trailing vortex structures which are associated with higher levels of turbulent kinetic energy relative to the remaining flow field.

Using immunoblot analysis we observed both, a significantly increased caspase-8 cleavage and DISC-formation upon TRAIL treatment with concomitant Notch1 inhibition.

The comparison of two theoretical studies by Helbing et al. and Goldstone et al. shows that although they adopted different terminologies for referring to the emergent patterns and deviations in the formation of the trail systems, the proposed core concepts both adopted for justifying the emergent trail patterns seem very similar.

We believe that the formation mechanism of trail system patterns in a flat, obstacle-free and uniform environment is the same as the trail system formation mechanism in a simple topology of nodes.