We present a numerical method that allows a formation of communicating agents to target the boundary of a time-dependent concentration by following a time-dependent concentration gradient.
We found that the high aspect ratio of the immunological synapse was insufficient in this regard, and that molecular crowding within the synapse is critical to preserve sufficient concentrations of perforin and granzyme for consistent pore formation and granzyme transfer to target cells.
In this chapter, we present recent developments on how enzymatically-triggered self-assembly of small molecules can be used to target the formation of hydrogels to biological spaces where specific enzymes exist.
ZnO film prepared by oxidization of sputtered Zn in low oxygen partial pressure possessed more oxygen vacancies that lead to the formation of more active sites to target gas and to be efficient gas sensor.
As a family of Ras-related small GTPase, Rabs function as coordinators for diverse aspects of intracellular trafficking including vesicle budding and formation, cargo sorting and transport to target membranes, and recruitment of key molecules (Stenmark, 2009; Zerial and McBride, 2001).
If amyloid fibrils were the proximate neurotoxins in AD, then a reasonable therapeutic approach would be to target fibril formation.
The objective of fibrinolysis is to target fibrin formation, to optimise evacuation of a thick fluid, and therefore to prevent both persistent PP and constrictive pericarditis.
Discerning the true relationship between inflammation and ankylosis is pivotal to future advances in disease modification because if these processes are largely uncoupled, future therapies will need to target bone formation pathways.
In summary, our results identify the crucial role of autocrine IGF1 in self-colony formation and emphasize the interest to target AKT, the shared downstream signaling target of IGF1R and C-KIT, for the treatment of MM.
Several new approaches designed to target the formation of β-amyloid aggregates are under investigation in clinical trials, with the aim of slowing or halting the progression of AD (refer to the Alzheimer's association page in the Further Reading section below).
