Sentence examples for formation the role from inspiring English sources

These data suggest that, in the context of elongasome formation, the role of the PBP anchor region could be to shield the head from untimely interaction with MreC and/or other protein partners, and that the N-terminal regions of PBPs play the role of protein interaction platforms, as previously hypothesized3, 20, 21.

Although significant efforts have been made to reveal mechanisms underlying cell tether formation, the role of nucleus, nucleus/cell volume ratio, nucleus/plasma viscosity ratio and cytoplasm/plasma viscosity ratio remains unknown.

Herein, we conduct detailed investigations to differentiate among several plausible mechanistic proposals, specifically addressing radical versus electrophilic addition to the indole during cross-link formation, the role of substrate side chains in binding in the enzyme active site, and the identity of the catalytic base in the reaction cycle.

This review discusses the fundamental aspects that need to be considered when using this model, such as selection of the animal species or in vitro system, timing and dose-responses of signaling events, metabolic activation and protein adduct formation, the role of lipid peroxidation and apoptotic versus necrotic cell death, and the impact of the ensuing sterile inflammatory response.

Given an obligate role for DNMTs in the suppression of non-B structure formation, the role of helicases in the process can be better understood.

The concept of the metastatic niche is still discussed controversially, reflecting the still limited number of publications in this area to date, as well as uncertainties regarding, for example, the relevance of DTCs to metastasis formation, the role of BMDC in tumor angiogenesis, and the precise definition of CD11b+ subsets.

With the aim to further comprehend CuS hexagonal plates formation, the roles of reaction temperature, Cu 2 + : S 2 O 3 2 − mole ratio and reaction time towards the crystal structures and morphologies of the final products formed were systematically investigated.

We have highlighted a few of the possible avenues a research programme could follow: early axis formation and polarisation, the specification of hypodermis, sex determination, vulva formation, the roles of epigenetic processes in developmental regulation and the confirmation of potential "phylotypic stage genes" with expression analysis in R. culicivorax.

Membrane-bound Gp120 may also induce apoptosis through syncytia formation, although the role of syncytia formation in in vivo infection is controversial.

MMP establishes vascular guidance tunnel that is essential for tube formation, so the role of MMP is neglected in signaling cascade of lumen formation.

These data suggests that the actions of PTEN(G129E) in potentially elevating intracellular PI 3,4,5 P3 are synergistic with SNX9 and SNX18 in elevating macropinosome formation, implicating the role of PI 3,4,5 P3 in SNX9 and/or SNX18-mediated regulation of macropinosome formation.