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The earliest step in vertebrate heart formation, specification of cardiac progenitors, is poorly understood.
Protocadherins are expressed throughout the nervous system and are involved in synapse formation, specification and maintaining, which make them potential candidate genes for schizophrenia.
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The approach allows to solve for different formation specifications in a decoupled manner.
The crucial step in DV axis formation is specification of the dorsal and ventral mesoderm.
While it is known that specific factors secreted from the tips of the ureteric tree are critical for the induction of nephron formation, the specification, segmentation and differentiation of non-tip regions of the ureteric epithelium is not well understood.
Barrow et al. [7] recently showed that axodendritic contact is closely followed by rapid accumulation of neuroligins that specifically interact and co-transport receptors such as NMDA (N-methyl-D-aspartic acid), thereby initiating formation and specification of synapses.
The epiblast proliferates to provide the substrate for axis formation, germlayer specification, and gastrulation.
During cardiac formation, cellular specification, differentiation, and rearrangement are tightly regulated by an intricate signaling network.
This pattern is founded during the formation and specification of neural stem cells.
Furthermore, it is well known that TFs are amongst the targets of the complex paracrine signalling pathways that underpin pattern formation, tissue specification, and differentiation in metazoans.
Here, we further explore the role of Oct4 in blastocyst formation and specification of epiblast versus primitive endoderm lineages using conditional genetic deletion.
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