From the biomass production view-point, the exhaustion of main substrates in the consortia is supplemented by utilization of the end-products through the formation of new subpopulations, thus maintaining or increasing the total biomass.
These results indicate genomic regions of interest for the formation of given subpopulations and provide new insight into the dissection of the genetic basis of complex traits.
This conversion is bidirectional within certain limits, resulting in dynamic variation of CSC abundance and heterogeneity of the tumour due to the formation of diverse subpopulations that support tumour growth in different ways.
Regardless, these data begin to define a molecular mechanism that appears to regulate the formation of a subpopulation of dendritic spines.
Both these studies show evidence that the treatment of TNBC with current therapeutics may result in the formation of a subpopulation of chemoresistant cancer cells with stem-like properties, that if not eliminated are free to form a tumour that is not responsive to current chemotherapeutics.
Furthermore, by using a Fst outlier approach we identified putative loci that can justify the formation of genetically differentiated subpopulations.
The genome doubling events subsequently led to the formation of two minor subpopulations (AA and AB) in the tumor that comprised approximately 8%and10%0% of the total tumor mass.
Each of these structures possesses some level of internal cell organization and complexity connected with the formation of differentiated cell subpopulations and also possesses a significant resistance to environmental impacts.
