Formation of products platforms is carried out during the planning stage and very often separately from the planning of corresponding assembly lines.
Therefore, the invention aspect of the patent not only involves the improvement of the product itself, but also involves the underlying technology and method of innovation, which is the basis of the formation of technology platforms and the implementation of independent innovation.
We propose that this is important for the formation of specialized platforms for their uptake.
Thus, formation of membrane platforms where Fas molecules are brought together may increase DISC formation and, therefore, potentiate Fas signaling.
NLRs are believed to initiate or regulate host defense pathways through formation of signaling platforms that subsequently trigger the activation of inflammatory caspases and NF-kB.
Various sensor proteins have been identified that can trigger the formation of inflammasome platforms.
Importantly, FasFc costimulation also resulted in a dramatic inhibition of TCR internalization, thereby preventing TCR translocation and the formation of signaling platforms essential for optimal T cell activation.
The formation of signalling platforms on the damaged membranes is regulated both dynamically (in time over the course of infection and spatially along the membrane-trafficking pathway) and functionally (via the post-translational modification-dependent recruitment of signalling molecules).
It has been found that Apaf has high structural similarity with NLR family proteins, which are thought to trigger or regulate host defense mechanisms through formation of signaling platforms that subsequently lead to activation of inflammatory caspases and NF-kB.
Cortical actin participates in the formation of signalling platforms with membrane receptor cytoplasmic domains (Xavier et al., 2004; Gajate and Mollinedo, 2005; Halayko and Stelmack, 2005; Chichili and Rodgers, 2009).
