Sentence examples for formation of mutants from inspiring English sources

Explanations for this finding might be either the formation of mutants of maspin [ 56] or the induction of maspin expression by chemotherapeutics [ 29] without a direct impact on tumor biology [ 48].

For instance, if IDH mutant:WT binding is weaker than mutant:mutant or WT WT binding, formation of the WT WT and mutant:mutant homodimers would outcompete formation of mutant:WT heterodimers.

While the importance of ER stress or proteosome malfunction in formation of mutant SOD1 aggregates has been established [35], [36], [40], the mechanisms by which mutant SOD1 forms LBHI/Ast-HI in FALS remain poorly understood.

The molecular mechanisms underlying the formation of mutant VAPB inclusions remain to be further determined.

(D – G ) NLK enhances the formation of mutant AR aggregates in a kinase activity-dependent manner.

On the other hand, transfecting a PSA RNAi construct enhanced the formation of mutant huntingtin exon 1 mCherry aggregates (Fig.  3C).

Therefore, we were able to detect a 'neutral' effect on pedestal formation of mutant that mimics phosphorylation by Erk, while the Erk non-phosphorylatable form blocked pedestal formation.

Third, using two subsets of structurally and spectroscopically distinct D-AAs, we achieved two-color pulse chase imaging, as demonstrated by observing aggregate formation of mutant hungtingtin proteins.

Furthermore, p35/Cdk5 was found to suppress the formation of mutant Huntingtin aggregates, a major pathological feature of HD, in primary cultured neurons.

In an animal model of Huntington's disease, creatine supplementation increased animals' life span, decreased their brain atrophy and delayed the formation of mutant huntingtin aggregates [ 25].

The key pathological features are the formation of mutant protein aggregates and selective loss of alpha motor neurons with increased autophagosomes.