Sentence examples for formation of initiation from inspiring English sources

PY binds exclusively to the 30S subunit of the 70S ribosome, and preventing the formation of initiation complexes by preventing the binding of mRNA and initiator fMet-tRNA to the ribosome [ 33].

Consistent with previous model, we found that Onc112 only moderately inhibits the formation of initiation complexes (Fig. S7).

DnaA generally acts as a repressor of transcription in B. subtilis, probably through blocking the formation of initiation complex of transcription and/or a transcriptional roadblock.

Potential functional significance of the distance of the core modules from the TSS might be interpreted in terms of the efficiency by which these core modules interact with the core promoter during the formation of initiation complex.

Once the formation of initiation complex takes place, the genome of HCV is translated to produce a large polyprotein that undergoes proteolytic cleavages with specific viral and cellular proteases to form 10 individual viral proteins, each of which has specific functions in viral life cycle.

During amino acid starvation, eukaryotic cells respond (1) by repressing the production of ribosomal proteins and rRNAs (Moehle and Hinnebusch, 1991) and (2) by phosphorylating eIF2α by GCN2, which retards the formation of initiation complexes (Krishnamoorthy et al., 2001; Zhang et al., 2002; Hinnebusch and Lorsch, 2012).

This enables eIF4E to be anchored to the 5′-cap structure of mRNAs, promotes the formation of protein initiation complex, and initiates protein synthesis.

Furthermore, Rib_30_ini_FORM is also proved to be the intermediate step in the formation of 70S initiation complex (70SIC) which regulates translation initiation, the rate-limiting step in protein synthesis [ 37].

The formation of 70S initiation complexes was then initiated by mixing the mixtures A and B in a stopped-flow instrument as described above.

4E-BPs bind to eukaryotic initiation factor 4E (elF4E) to prevent the formation of protein initiation complex and protein translation.

Phosphorylation of eIF2 α then reduces the formation of translation initiation complexes, resulting in reduced recognition of AUG initiation codons, thereby decreasing the levels of unfolded protein in the ER.