Sentence examples for formation of disease from inspiring English sources
To establish a mouse model for endometriosis and to evaluate roles of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) in the formation of disease.
Alternatively, this region of the N-terminal domain of PrP may serve as a site that mediates β-sheet enrichment during the formation of disease associated PrP.
A uniform distribution of points without formation of disease groups (ICD-10 categories: musculoskeletal, circulatory, respiratory, nervous system or digestive, based on the primary diagnosis given by the ward physician) would indicate no confounding by the factor "type of disease".
For studies of genetic function or formation of diseases, the sex influence can potentially obscure the methylation disease association results.
It is not only essential for normal cellular development, but also may be associated with formation of diseases.
Inhibition of small oligomer formation of disease-linked proteins therefore represents a therapeutic approach with potentially broad applicability to many neurodegenerative disorders.
A common finding in autoimmune diseases is activation of autoreactive B lymphocytes, resulting in the formation of disease-specific autoantibodies [ 6, 7].
In vivo, we see a diversion of formation of disease-associated oligomers to smaller oligomers and monomers by anle138b treatment for both PrPSc and α-syn (Figs. 4a, b; 8e, f).
Alzheimer's disease (AD) and a range of related disorders are associated with the self-assembly, aggregation, and fibril formation of disease-specific peptides and proteins [1]; in the case of AD such processes are involved with aggregation of the amyloid-β (Aβ) peptide [2], [3].
Together, these data strongly suggest that the protein folding activity of the large ribosomal RNA plays a role in PABPN1 aggregation in OPMD, and strengthen the hypothesis that ribosomal RNA has a general function in the formation of disease-related amyloid fibers.
Moreover, redox signaling is a critical event in several inflammatory diseases such as AD that precedes the formation of these disease pathologies.
