Wnt induces polyubiquitination-mediated proteasome degradation of Axin, an event that is believed to impair the formation of sufficient destruction complex, facilitating Wnt-induced β-catenin stabilization.
8 24 In normal cells, proteasomal β-catenin degradation proceeds through the formation of a destruction complex, limiting nuclear translocation and transcription of β-catenin-dependent genes.
Therefore the onset of JRA is often assessed as an event of arthritis associated with infections (AAI), which precludes an early initiation of aggressive treatment with disease-modifying antirheumatic drugs to have an impact on the formation of joint destruction mediated by cathepsins and matrix metalloproteinases (MMPs).
VIP has been demonstrated to play an important role in the control of osteoclast formation because destruction of nerves expressing VIP by guanethidine treatment increases the number of osteoclasts [ 69].
These works are based on the evolutionary model of elemental abundance in galaxies called the chemical evolution model (Tinsley, 1980 for a review) and incorporate some (or all) of the three processes of formation, destruction, and growth of dust.
A supra-molecular lattice model for simulating textures in liquid crystals is utilized to simulate the effect of an applied field on a nematic, and the role of disclinations in the formation and destruction of the network of walls is considered.
When the rate of bone resorption exceeds that of bone formation, destruction of bone tissue occurs, resulting in a fragile skeleton.
Sections were examined for the presence of hyperplasia of the synovium, pannus formation, and destruction of the joint space.
The influence of pressure on the heterogeneous formation and destruction of NO and N2O during the burning of char was studied in a pressurized fixed-bed reactor.
The addition of reactions involving the formation and destruction of benzylperoxide radical was crucial to modeling toluene shock tube data.
Oral histories describe the formation and destruction of the Bridge of the Gods, a land bridge that connected the Oregon and Washington sides of the river in the Columbia River Gorge.
