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The synthetic routes reported in the literature for the formation of derivatives of 6,7-alkoxyisoquinolines as selective PDE10A inhibitors involved multi-step reactions ranging from 3 to 13 steps [67, 68].
This idea was further reinforced by the observation that trapping of the reaction intermediates with iodine, iodomethane, or carbon dioxide, as opposed to a proton, leads to the formation of derivatives 9– 11 (Scheme 5).
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The formation of derivative (5) is indicated by the presence of (C=N) groups in the IR spectra (Fig. 3b) at ν 1593 and 1614 cm−1, respectively, besides no bands of hydroxyl and cyano groups were observed.
Such changes in ploidy are termed meiosis-like adaptation (Storchova 2014) and can result in the formation of derivative and hybrid cells with diverse genotypes and phenotypes, even from the same parental polyploid strain.
Furthermore, the formation of fluoro derivatives or α,β-unsaturated compounds derived from a Meyer Schuster rearrangement 16 was not observed either in the model reaction or during the study of the scope of the reaction.
Chemical reduction of aromatic diazonium salts leads to formation of hydrazine derivatives.
The cross-linking reactions are quite complex, but they essentially involve the addition of atmospheric oxygen to the fatty acids, leading to the formation of hydroperoxide derivatives of the fatty acids.
Successive elimination of H2O results in the formation of oxathioacetal derivatives and regenerates SANM in the reaction mixture.
Successive elimination of H2O results in the formation of quinoxaline derivatives and regenerates TiO2-Pr-SO3H in the reaction mixture.
Fig. 1 Formation of indolinone derivatives for both diclofenac-Na and 4-hydroxydiclofenac in the presence of derivatising agent PFPA.
Condensation of 2-acetylcycloalkanones with a variety of aromatic aldehydes resulted in the formation of 2-arylidene-6- 3-arylacryoyl -cycloalkanone 2-arylidene-6- 3-arylacryoyl -cycloalkanone 2-arylidene-6- 3-arylacryoyl -cycloalkanone 2-arylidene-6- 3-arylacryoyl -cycloalkanone 2-arylidene-6- 3-arylacryoyl -cycloalkanone 2-arylidene-6- 3-arylacryoyl -cycloalkanone
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