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Several antimitotic drugs including the taxanes and the vinca alkaloids, via their effects on microtubules, prevent the formation of a normal mitotic spindle, resulting in spindle checkpoint activation.
These findings indicate that the formation of a normal eye-specific segregated pattern may require an expression pattern of specific genes during the first postnatal week that is altered in the Chrnb2−/− mutant LGNs.
PE is an event after formation of a normal zygote.
The formation of a normal functional stratum corneum requires both extracellular lipid membranes and corneocytes ("bricks and mortar").
Interference with NuRD function by deletion of the Mbd3 gene abrogates the formation of a normal epiblast possibly caused by inappropriate trophectodermal differentiation (Kaji et al. 2007).
In this regard, the function of Zfp335 is similar to its action in the brain where it is needed for the formation of a normal sized forebrain structure (Yang et al., 2012).
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The same study also showed that reduced levels of glycylation cause the formation of a structurally normal but unstable sperm axoneme, similarly to what we saw in Bug22 flies.
Moreover, E2 was found to be essential for the formation of normal amount and normal length fibrils, which could explain the very low plateau height observed in the ThT assay for this mutant.
Higher concentrations of peptide (10 15%) led to the formation of a mixture of normal hexagonal phase and lamellar phase lipids.
Using CSF-1 deficient csf-1op/op mice, they showed that absence of microglia in the postnatal mouse retina correlated with the formation of a sparser than normal retinal vessel network.
Chronic myeloid leukemia (CML) is characterised cytogenetically by the Philadelphia translocation (t(9 22)), which results in the formation of a smaller than normal chromosome 22 known as the Philadelphia chromosome, and the derivative chromosome 9 (der(9)) [ 7].
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