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The make up of the formation is unclear.
The detail mechanism of Cthrc1 during bone formation is unclear.
To which extent each of these plaque components contribute to thrombus formation is unclear, though the platelet-activating roles of VWF and collagen are well-described [1].
Although the precise mechanism by which Podocalyxin induces microvillus formation is unclear, it may be largely biophysical; the formation of microvilli may simply serve as a mechanism to distribute Podocalyxin's bulky extracellular domains more evenly across the cell surface.
The role of OPN in nephrolithiasis formation is unclear.
Until now the influence of relaxins on spontaneous metastasis formation is unclear.
Similar(42)
Although ESCRT-III drives membrane remodeling that creates MVBs, its structure and the mechanism of vesicle formation are unclear.
Specific mechanisms responsible for the CMITEs array formation are unclear, but could be related to their similarity to the autonomous piggyBac transposons, which are also able to form large tandem arrays [34].
CD8+ T cell responses can provide effective pathogen clearance, as well as long-term protection against pathogens due to their ability to develop into memory cells, however, the mechanisms that govern the highly dynamic processes of proliferation, contraction and memory formation are unclear [3].
The nature and the length of the time interval between inflammation and new bone formation are unclear.
Although a recent Cochrane review determined that the effects of long term high-dose NSAID treatment on syndesmophyte formation was unclear [ 5], other recent studies have indicated chronic high-dose NSAID treatment [ 6– 8] or long-term TNF blockade [ 3, 9] may be effective at slowing progression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com