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Abnormal deposition of α-synuclein has been linked to the pathogenesis of neurodegenerative diseases, and missense mutations of the human gene, such as A53T, increase the probability of aggregate formation (for review see, [40], [41].
This influences cellular differentiation and apoptosis and thus tumor formation (for review see Refs. [19 22]).
In previous work we and others have studied the role of L1CAM in cell motility, invasion, chemoresistance and metastasis formation (for review see [ 17, 18]).
Bacteria can communicate through quorum sensing signals, and they use quorum sensing to regulate a number of physiological activities, e.g. symbiosis, virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation (for review, see [ 1, 2]).
Carbohydrates control cell cycle activity and are known to influence plant development and organ formation (for review see: [ 50, 51]), but a role in trichome development has not been reported.
The impact of aging-associated alterations in the expression of mitosis/chromosome-regulating genes on initiation and clonal dominance of stem and progenitor cell mutations remains to be investigated, given the evidence that failures in chromosome segregation can induce loss of heterozygosity and cancer formation (for review see Ricke et al., 2008).
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Up-regulation of Flotillin-1 after spatial learning in the mouse hippocampus is likely to reflect similar structural rearrangements including generation and maturation of dendritic spines, (24) necessary for long-term memory formation (see for review: (26)).
After transplantation into immunodeficient mice, tumors form from several hundred marker-positive cells, whereas for marker-negative cells orders of magnitudes higher numbers are needed to achieve the same frequency of tumor formation (for a review: see [15].
Thank you for submitting your work entitled "The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation" for peer review at eLife.
Thank you for submitting your work entitled "Single molecule compression reveals intra-protein forces drive cytotoxin pore formation" for peer review at eLife.
[Editors' note: what now follows is the decision letter after the authors submitted for further consideration.] Thank you for submitting your work entitled "Reward signal in a recurrent circuit drives appetitive long-term memory formation" for peer review at eLife.
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