Click, click, click, click, click.
The principle advantages of oxime formation by click reaction between an aminooxy- and a carbonyl functionality for F-fluoroglycosylation are its high chemoselectivity, the use of unprotected aminooxy precursors, and the fact that coupling with the carbonyl component can be performed in aqueous media (pH 4 7).
These silicon groups bearing an acid or an azide group were coupled to a model tripeptide (Leu-Gly-Gly) either through a classical amide bond formation or through "click chemistry" via the Huisgen cycloaddition.
The biomolecules are attached to the prosthetic groups mostly through amine- or thiol-reactive groups via acylation, alkylation, amidation, imidation, oxime, hydrazone formation, or using click chemistry (described below).
The now designable four-arm star polymers enabled the design of a highly efficient self-healing system based on double network formation due to "click -crosslinking and supramoleclick -crosslinkingtion.
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Similar to the labeling strategy using oxime formation for labeling, the click chemistry approach also reduced the overall synthesis time compared with [F]Galacto-RGD, thereby increasing the availability of [F]RGD-K5 [ 30].
Formation of the involutes: Clicked the toolbar 'Insert Benchmark Curve', selected 'From Eq', 'Cartesian coordinates' and set 't = 0 − 1', then entered the involute Eqs. in the pop-up text page.
The click chemistry allowed formation of a 1,2,3-triazole between azide on the PEG terminal and alkyne on the DNA.
