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Interestingly, TNF-α particularly in the format of fusion proteins (like L19TNF-α) is able to target selectively angiogenic tumor vessels, to enhance the tumor penetration and to improve the antitumor therapeutic efficacy of chemotherapeutics-like melphalan 9– 37 or gemcitabine 21.
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In this study we present a new format of TRAIL fusion proteins based on directed dimerization with strongly increased tumor-targeted bioactivity and devoid of systemic toxicity of these TRAIL fusion proteins.
To circumvent or at least minimize these potential problems, we have developed a new format of a TRAIL fusion protein based on scTRAIL, a single polypeptide chain composed of three TRAIL monomers.
In this study, a novel format of EGFR/MMP-2 bi-targeted fusion protein Ec-LDP-TIMP2 and its enediyne-integrated analogue Ec-LDP AE -TIMP2 havEc-LDP AE -TIMP2by Ec-LDP AE -TIMP2ing and molecular reconstitution.
The sABs are displayed in bivalent format by fusion to the pIII coat protein of M13 phage.
I made a soufflé of Fusion!
We have had decades of fusion food.
Mr. Cheung shows no fear of fusion.
Sidebar: Two Views of Fusion.
The new shape of fusion.
The feature-level fusion is the simplest way of fusion.
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