Only the classified terms of the nomenclature (a total of 126,756 terms) were used in this exercise to avoid formatting inconsistencies present in terms that are pending classification.
Even among those datasets that were made available, inconsistencies in formatting and labelling mean that this fraction is reduced further such that only a tiny amount of usable data is truly available even when the right technical infrastructure is in place.
For the different steps of the linkage analysis; e.g. data formatting, detection of Mendelian inconsistencies, mistyping analysis, LD removal and single to multipoint linkage analysis, we have chosen the following programs that can handle large pedigrees and many SNPs where required; Alohomora [ 32], Mega2 [ 33], MENDEL [ 30], SNPLINK [ 29] and SimWalk2 [ 31].
However, others have expressed concerns regarding the complexity of the HMR process, time constraints and inconsistency in the reporting format and quality [ 6, 10, 11].
Data submissions undergo internal evaluations to look for inconsistency in the data format and any missing or unreliable information, before getting uploaded to the database.
We also cross checked the data from the health management information system (HMIS), district reports, reporting formats, and hospital registers and no major inconsistencies were observed.
However, the data was recorded using a standard format among the registries and therefore, any inconsistency in reporting would have been a random event independent of maternal age.
Like FourMatch, its software examines image files to look for inconsistencies in colour, encoding and compression formats that indicate the use of retouching software to modify the image.
One early academic champion was the Parisian master Abelard, who cunningly used the format of the disputation to point up the apparent inconsistencies in orthodox Christian doctrine.
