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We create the module to transform machine time format to human time format in module Pre-processing III.

Multiple genome alignments in maf format for human (46way) and mouse (60way) have also been downloaded using the UCSC table browser [ 88].

For a consistent comparative analysis, the tool LiftOver was used to convert genomic coordinates in BED format from human to canine, using the UCSC [ 13] chain file for hg19toCanFam3 as reference.

Nevertheless, it is also well recognized the difficulty of collecting such kind of information through scientific literature, especially when the number of considered proteins is large, because scientific literature contains PPI data in the unstructured format of human natural language.

In this research, we transform machine time format to human time format.

GERP RS scores in BigWig format for the human reference genome hg19 were downloaded at http://hgdownload.cse.ucsc.edu/gbdb/hg19/bbi/All_hg19_RS.bw.ucsc.edu/gbdb/hg19/bbi/All_hg19_RS.bw

The Burrows-Wheeler aligner [ 13] was used to align the raw reads from each sequencing lane (in fastq format) to the human reference genome (NCBI37/hg19) using default parameters.

The details process in the Pre-processing III module as follows: 1. Converting machine time format to human time format.

Converting machine time format to human time format.

Additionally, the user can retrieve all relevant data in human readable format in a very convenient way.

✓ Executable representation must be available in human readable format for review by SMEs and other business people.

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