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None of the associations seen in the enhanced replication data would remain formally significant after adjustment for 527 (572–45) comparisons, since the lowest p-value was 0.005.
One-third to one-half of the formally significant associations have moderate or large I values.
Four of the six correlations were found to be formally significant, however two of these demonstrated minimal associational strength.
Although this is not a formally significant enrichment for candidate genes, a p-value of 7.5% is suggestive of enrichment.
This test is not formally significant; this should be kept in mind while interpreting results based on haplotype analysis.
While four of the six correlations were formally significant, the large sample size risked Type I errors.
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As often happens, the discipline of writing papers formally generates significant new ideas and insights.
The heterogeneity test (Cochran's Q statistic) was formally statistically significant for the FTO variant (p = 0.014) and the rs9300039 marker (p = 0.018).
There was larger, but still not formally statistically significant heterogeneity for the other 3 SNPs that were selected by 2 of the 3 strategies (I2 ranging between 24% and 49%).
Differences between male and female trends were only formally statistically significant for gonadal tumours in children and melanoma in adolescents/young adults.
On the other hand, the odds ratio was less prominent and not formally statistically significant among women (odds ratio 1.56, 95% CI, 0.44-5.48).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com