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We identified 15 loci that were genome-wide significant (p < 5 × 10−8) in stage 1 and formally replicated in stage 2. A combined stage 1 and 2 meta-analysis identified 66 additional genome-wide significant loci (13, 35, and 18 loci in European, African, and trans-ancestry, respectively).
None of the initial findings could be formally replicated.
The observed differential association was not formally replicated in the BCAC studies since the direction of the HRs in the subgroups by chemotherapy in BCAC was opposite to that in the MARIE study.
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Nor could we formally replicate any polymorphism that has been previously associated with cognition, although we found a weak signal of lower than expected P-values for variants in a set of 10 candidate genes.
We could not formally replicate the associations of FOXO3Avariation with ADL and bone fracture in another sample of Danish oldest-olds.
Although the single-SNP associations did not formally replicate in another study population of oldest-old Danes (n = 1279, age 94 100), the estimates were of similar direction of effect as observed in the Discovery sample.
Formally, he is available.
A particular feature of this microarray is that component ESTs of many contigs and clusters provide replicate data (formally, quasi-replicate since the characteristics of each arrayed amplicon are not identical) for measurement of gene expression.
Switzerland formally agreed to replicate its agreement with the EU for the UK yesterday, allowing Britain to carry over preferential tariffs and terms after leaving the bloc.
To formally test whether these circuits can be dissociated, we extracted their corresponding seed regions in the cerebellum and frontal cortex and formally tested, in an independent data set, whether differential correlation could be replicated.
However, formally these are convolutional networks, so that the neuronal filters for one local region are replicated over the whole of visual space, which is computationally efficient but biologically implausible.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com