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While we cannot formally refute this possibility on the basis of the available data, we consider this to be an unlikely hypothesis.
To formally refute all four statements would require several courses in Biology.
Still, we cannot formally refute the reversal scenarios here, given the lack of statistical support, and briefly discuss them in the below.
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The hypothesis that at least some cases of apparently sporadic CJD are due to unrecognized BSE infections cannot be formally refuted, but if correct, we might expect by now to have some epidemiologic evidence linking BSE to at least 1 cluster of apparently sporadic cases of CJD.
While the experimental evidence indicates that immunity can be induced early in ontogeny [ 5– 9] and tolerance can be induced in the periphery of adult animals [ 10], thus formally refuting the original models, the idea that immature lymphocytes are predisposed to tolerance has remained a powerful concept in the field of self tolerance.
In any case, we stress that further studies will be required in the future, perhaps involving the selective deletion of LKB1 in the hypothalamus by the injection of Cre recombinase into this brain region in LKB1 flox'd mice, to formally confirm or refute the possibility of distinct roles for central and pancreatic islet LKB1 in the control of glucose homeostasis and food intake.
"I refute it thus".
I refute it unequivocally".
I refute that hugely.
And I refute this".
I refute that heartily".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com