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The algorithm used to find the optimum pulse is also relevant; we test both direct gradient-free algorithms, as well as schemes based on formal optimal control theory.
Furthermore, a pharmacometric model based power can be combined with a formal optimal design to pin down the most informative clinical trial design in terms of both study power and parameter precision.
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This paper provides a formal optimization treatment on optimal designs with generalized minimum aberration.
Formal optimization strategies normally evaluate hundreds or even thousands of scenarios in the course of searching for the optimal solution to a given management question.
The problem of optimal selection of a subset from a larger group of potential habitat sites is solved using either heuristic or formal optimization methods.
To plan such a network is to describe a formal and optimal flow of knowledge as the basis for effective teamwork.
Investigators and grant peer review committees should consider prioritizing less-studied topics or requiring formal consideration of optimal information size based on extant evidence in power calculations.Journal of Perinatology advance online publication, 7 September 2017; doi 10.1038/jp.2017.126.
We will consider questions of (1) how to perform valid statistical inference using differentially private data or summary statistics, and (2) how to design optimal formal privacy mechanisms and inference procedures.
The American College of Medical Informatics Task Force takes no formal position on optimal length of training for health professionals interested in informatics [ 28].
In order to solve this problem, Qian and Dougherty [ 95] derived a formal characterisation of optimal structural intervention, based on the general perturbation theory in finite Markov chains.
In particular, we give a formal definition of an optimal L2 gain based anti-windup design problem in the global, local, robust and nominal cases.
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