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A formal burden test for each new gene should be performed.
The objective of the study was primarily exploratory and these data do not represent a formal burden of illness study.
More formal burden and risk assessment will become available as documentation of the catchment population of these hospitals and wards improves.
The formal burden test is generally used for complex diseases with a large number of samples (Nat Genet. 2012, 29;44:623-630; Hum Mol Genet. 2012,21 R1-9).
It would also be informative to perform a formal burden test for these 2 genes to document enrichment for novel/rare and predicted deleterious variation in association with phenotype.
Similar(55)
Most important, establishing formal teams removes the burden of intra-organizational networking from the salesperson.
The excessively formal language is a burden to many businessmen, especially those working in small companies.
It also formed an escape route for artists from the burden of formal values in the academic tradition.
In the absence of previous formal study, the actual burden has not been clearly understood.
Because the Spanish population is aging rapidly, the burden of formal and informal care may increase significantly in the future.
Because the Spanish population is aging rapidly, the formal and informal care burden may increase significantly in the future.
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CEO of Professional Science Editing for Scientists @ prosciediting.com