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The model form used was: Instantaneous Load = a_{0} + a_{1} ln Q a_{2} sin left( {2pi dtime} right) + a_{3} cos left( {2pi dtime} right) (3)where lnQ = ln stream flow) − center of ln stream flow); dtime = decimal time − center of decimal time and a 0 to a 3 are model coefficients.

Although the case-report form used was designed to obtain a detailed medical history, patients and guardians were not always good historians.

All participants provided voluntary written informed consent when enrolling in the main MRC HIV Clinical Cohort and the original consent form used was included as part of the ethical review for this study.

Table  3 shows that only 179/658 (27.2%) of respondents practiced dual method of contraception, indicating a low or poor uptake; the commonest (141/179; 78.9%) form of dual method used was a combination of condom and injectable hormonal contraceptives, while the least (2/179; 1.3%) form used was a combination of condom and intra uterine contraceptive device (IUCD).

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The form used is shown in Figure 1.

The standardized form used is provided in the data file.

The Consent Form used is shown in Additional File 1.

An image of the form used is shown in Figure  2.

It is clear that in the limits X << Y and Y << X, the form used is sensible, but this is never discussed clearly.

The forms used were developed in cooperation with YC, Orrick, Imagine K12 and an incubator named Boost.

The most popular linear forms used are Langmuir-1 and Langmuir-2.

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