This form of sensitization has been variously referred to as "conventional" or "nociceptive" sensitization [ 39] or "extrinsic" sensitization [ 10, 27, 37, 42, 48, 49].
This form of sensitization is related to changes in the properties of primary nociceptive afferents (peripheral sensitization), whereas central sensitization requires functional changes in the CNS (neuroplasticity).
Thus, dishabituation may represent a form of sensitization that is gated by habituation (see Sect. 4.3.2).
However, this form of sensitization is clearly distinguishable from the first, which was elicited by the primary stimulus itself.
For instance in addiction, protein co-regulation as a form of sensitization is well-attested, but also in cancer where intercellular signaling (e.g. by cytokines ) is affected.
Kindling is a form of sensitization in which repeated application of electrical stimuli applied to the brain at low levels culminates in the induction of full-blown seizures when the same stimulus is applied at a later time.
Activation of several protein kinases causes both forms of sensitization via posttranslational, translational, and transcriptional regulation.
Thus, a stimulus could sometimes induce both forms of sensitization simultaneously rather than one or the other exclusively.
Different forms of sensitization include limbic kindling of seizures (compare temporal lobe epilepsy and simple partial seizures) and time-dependent sensitization of behavioral, neurochemical, immunological, and endocrinological variables.
These inefficiencies had implications for program cost-effectiveness by limiting beneficiary time spent in vegetable production, training sessions and other forms of sensitization.
