Exact(10)
In principle, any viral RNAs sharing common miRNA response elements with host mRNAs could potentially act as cvhRNAs and form regulatory networks across the transcriptome.
Instead of acting as defenders like siRNAs (except tasiRNA) or piRNAs, miRNAs participate in the regulation of a wide range of endogenous processes including development, metabolism, stress response etc., and often form regulatory circuits with transcription factors [11], [12], [13].
These and additional processes (for example mitochondrial ribosomes or ubiquitination), form regulatory modules of physically interacting proteins, as seen in Figure 5, regulating the biogenesis and morphology of peroxisomes.
These networks could take the form of multiple instances of these cascades in serial arrangements or in interlinking networks and have the potential to form regulatory circuits and switches in a manner similar to that of the gene expression network, if these networks do exist they could comprise a huge layer of genetic control and information processing.
During the past decades, it has been reported in several studies that transcription factors and microRNAs form regulatory circuits, where transcription factors regulate microRNA transcription, which in turn controls the expression levels of transcription factors post-transcriptionally [4], [5], [6], [7].
These binding sites form regulatory networks which determine the dynamics of many critical developmental and cellular processes.
Similar(50)
On February 28th a task force charged with producing recommendations for the Colorado legislature will issue its report.Though non-binding, this will be the first glimpse of what a fully formed regulatory regime for legal cannabis may look like.
Among the elements forming regulatory networks in bacteria are regulatory proteins such as transcription factors, which respond to exogenous and endogenous conditions.
Since transcription factors usually co-regulate a common group of genes by forming regulatory modules with similar TFBSs.
Another network shows that the GATA family of TFs interconnects and forms regulatory circuit with the other six TFs including NFE2, NFIL3, RUNX1, NKX3-1, Tand, and FLI1.
This reflects an important underlying trend of WGD evolution, namely the preferential cross-connectivity of newly formed regulatory pathways with ancestral ones.
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