It is a precarious process of stabilising the relational order.
Before the start of experiments, cultures were placed in minimal medium in the presence or absence of CDDOTFEA (100 nM), 16 h before an oxidative insult was applied in the form of H2O2 (100 μM, stabilised solution; Sigma).
However, its expression is lost during the evolution from adenoma to carcinoma, whereas p53 expression is increased, an event generally coincident with the expression of stabilised p53, which we presume to represent the mutant form.
The role of small particles in forming and stabilising the deformation structure is discussed.
Studies of the blebs mice suggest that the proteins form a mutually stabilising complex that acts at the interface between the basement membrane lamina densa and its underlying dermis, and seems to be crucial for epidermal consolidation.
The lack of eukaryotic chaperones, specialised post-translational modifications, ability to be targeted to sub-cellular locations or to form complexes with stabilising binding partners can result in protein mis-folding and aggregation.
Hydrogen bonding is most prominent among the beta turn forming residues thereby stabilising the connecting link of helices and strands.
A review of five previous studies in the UK, Sweden, the Netherlands and Spain has found signs that the number of people with Alzheimer's and other forms of dementia is "stabilising".
The antibody detects a stabilised form of the protein that, if not stabilised through mutation, is stabilised through other means, which results in an interruption of the degradative pathway of wild-type p53 (Wynford-Thomas, 1992).
Rugged folding landscapes result as a consequence of the need to form the thousands of weak, stabilising interactions which are present in the native state (reviewed in Ref. [31]).
