Sentence examples for form of plaques from inspiring English sources

But he added that the 3.5-acre park should have a "significant memorial," in the form of plaques or designated areas.

Selective application of metal chelators to homogenates of human Alzheimer's disease (AD) brain has led us to propose that the architecture of aggregated β-amyloid peptide, whether in the form of plaques or soluble oligomers, is determined at least in part by high-affinity binding of transition metals, especially copper and zinc.

Along with the normal sight changes that accompany aging, damage to the brain in the form of plaques and tangles, which are hallmarks of Alzheimer's, can occur in the part of the brain responsible for transmitting visual information.

Cells were then incubated at 37°C until development of cytopathic effects in the form of plaques which usually occurs within 2 3 days.

In Alzheimer's disease, the discussion on the impact of the large Aβ aggregates in the form of plaques on the clinical disease course has lasted for decades.

In a systematic study of the different types and assembly states of Aβ that accumulate in Tg2576 mice, Kawarabayashi and colleagues [ 34] showed that Aβ in the form of plaques appear as early as 7 8 months whereas diffuse plaques appear between 12 and 15 months.

Among several pathogenic organisms that accumulate and colonize in the form of plaque, lactobacilli do not play a major part in initiation but are important in progression of the lesion.

These abnormal protein aggregates are observed within muscle fibres in the form of plaque-like or dotty inclusions [ 8].

Whether therapy with TNF-antagonists may induce a more severe form of plaque psoriasis or psoriatic arthritis in some patients treated for these indications is difficult to determine, as the natural course of both plaque psoriasis and psoriatic arthritis is variable and a loss of effect is not easily differentiated from an induction of a more severe form of the respective disease.

The two well-described forms of plaques have been termed diffuse plaques and neuritic or senile plaques [ 12, 18], although other intermediate forms such as fibrillar plaques have been described [ 12].

Future studies using TREM2 and Tmem176b KO and overexpression models should help define whether specific forms of plaque-associated microglial activation should be promoted to provide neuroprotection during immune therapies.