With the availability of whole genome sequences of several clinical isolates [2], [3], [4], the genetic diversity of M. tuberculosis has been chronicled in the form of insertions, deletions, and single nucleotide polymorphisms (SNP).
Chromosomal length polymorphisms (CLPs) were found to be in the form of insertion-deletion events (Indels) over 3 10 kbp in size, occurring within transition zones between rDNA units and chromosome cores [ 10].
We recently reported a previously unrecognized form of polymorphic insertions, termed templated sequence insertion polymorphism (TSIP), in which the inserted sequence was templated from a distant genomic region, and was inserted in the genome through reverse transcription of an RNA intermediate.
Often this has left agencies with no other choice than to adopt basic life support level airway management skills, often in the form of blind insertion devices.
Structural variations (SVs) in the form of deletions, insertion, chromosomal translocations or inversions were observed in 8% of all mate pairs (range 3% - 15%, Additional file 2 and Additional file 3).
However, more thorough sequence analysis revealed that the full conserved form of the insertion is limited to vertebrates, and is not in fact a universal attribute of mIF2 [ 99]. mIF2-2 is a duplication of mIF2 found in some excavates and apicomplexa [ 99].
An international group of scientists reported in June in the journal Nature that patients suffering from ASDs had in their genes a higher incidence of mutations in the form of deletions, insertions or duplications of segments of DNA than unaffected control subjects.
These error-prone pathways significantly contribute to genome instability in the form of CAs, insertions or deletions and subtle mutations.
