Sentence examples for form of dca from inspiring English sources

We raised two questions: how to introduce physiologically relevant DCA doses into cancer cells and how to engineer the anionic form of DCA to partition across the inner mitochondrial membrane (IMM) and the negative Δψm that exists across this membrane into the matrix to access PDK1?

In contrast, when multiple DCA molecules were delivered directly to the mitochondria using a single TPP moiety in the form of Mito-DCA, a remarkable increase in cytotoxicity in all three PCa cell lines was observed.

In addition Cai and Guengerich (1999) reported that a significant amount (about 35%) of DCA is formed from aqueous decomposition of TCE oxide via hydrolysis in an almost pH-independent manner.

For other happy haunts, visit Candy Corn Acres at DCA. Goofy is trying to grow a candy corn farm in the main plaza of DCA but of course it comes out a little Goofy.

Effective lactate reduction in tumor cells by precise targeting of DCA to the mitochondria of cells in the form of Mito-DCA not only can change the tumor cell glycolysis efficiently but also has the potential to alter the immunosuppressive environment modulated by lactic acid.

In the dose of 0.3 mg DCA/mouse per day, we did not find any impact of DCA on the development and course of CIA (data not shown).

Serum concentrations of free LCA were very much lower than those of DCA and the bulk of LCA is present in a sulphated form which was not measured by the methodology employed in this study.

These Dex-DCA-DOX prodrugs self-assembled to form micelles under physiological conditions with varied particle sizes depending on molecular weight of dextran, degree of substitution (DS) of DCA and DOX.

Dichloroacetate (DCA) is a mimetic form of pyruvate, and among several glycolytic inhibitors it is known to significantly decrease lactate production in myeloma cancer cell lines [ 96].

The decreases in the levels of DCA conjugates (glycodeoxycholic acid and taurodeoxycholic acid) and glycolithocholic acid were not significant.

Towards this direction, one promising category of DCA mechanisms, which has been recently studied in the literature, refers to the channel segregation-based DCA (CS-DCA) mechanisms [10].