Sentence examples for form docking from inspiring English sources
Subsequently, active Jaks phosphorylate tyrosine residues within the receptor cytoplasmic domain, which form docking sites for STATs.
Specific residues on MAP kinases form docking domains that determine binding specificity with substrate proteins.
The dimers form docking sites for the recruitment of cytoplasmic enzymes and adapter proteins, starting a complex signaling cascade [ 5].
When phosphorylated, these motifs form docking sites for the BUB1 BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint.
Dually phosphorylated ITAMs, in turn, form docking sites for the tandem SH2 domains of Syk family kinases, ZAP-70 and Syk.
LAT is phosphorylated on multiple Y residues, which then form docking sites for other adapter proteins like SLP-76, Grb-2 and Gads, and enzymes such as PI3K and PLCγ1 [37].
The top-ranked binding mode for the A66 S form docked into the p110α ATP-binding site (PDB code 2RD0), after minimization and rescoring with the kinase modified Chemscore scoring function using receptor depth scaling, is shown in Figure 2. Critically in this predicted binding mode, the ligand forms an interaction with Val of the inter-lobe linker region.
Binding of IL-23 to its receptor causes activation of Janus kinases (Jaks) which phosphorylates IL-23R at certain locations, thus forming docking sites for the STATs, and further enabling them to translocate to the nucleus where transcription of pro-inflammatory genes such as IL-17 and interferon-γ (IFN-γ) are initiated [ 19].
As summarized in Fig. 5C, neither the W173A, the L146A/L165A nor the L146A/H177A mutants were able to form stable docking heads.
Clustering of -boxes, resulting from Ire1 LD-driven oligomerization, would generate the required synergistic avidity, such that only clustered -boxes form a docking platform for the mRNA.
Actually, once inserted, the PMP assemble to form the docking (node 16560), translocation (node 6625) and receptor recycling (node 16562) complexes.
