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Although HER2 appears to have no intrinsic ligand-binding capability, it can interact reversibly with ligand-activated EGFR or HER3 to form active heterodimers which activate downstream signals to govern cell proliferation and migration.
These activities will be added up to form active and passive engagement scores, which will then be combined to form a third total engagement score.
In conclusion, trimers dimerize to form active hexamers efficiently at 50 nM, and their activity is higher than that observed for FtsK50C at the same concentration.
The RL species catalyzes the activation of the heterotrimeric G-protein (G) to form active α-subunit (Ga) and free Gβγ (Gbg).
According to the previous study [29], we believe that the implanted MWCNTs form active centers on the surface, which may increase the catalytic activity of the blood components.
The result is activation of matrix metalloproteinases by cleavage of zymogens to form active moieties such as collagenase and stromolysin.
The activated caspase (caspase-9) cleaves the executioner procaspase (procaspase-3) to form active executioner/effector caspase (CEA), whereby the apoptotic response is irreversibly triggered [ 11].
We note that the TRIP13W221A single mutant has comparable activity to fully-stimulated TRIP13, strongly supporting the notion that it can form active hexamers.
Many other zymogens or precursors undergo proteolysis to form active enzymes or proteins (e.g., fibrinogen to fibrin).
BRD4 is known to form active transcription complex, which consists of CDK9, CYCLIN T, and BRD4.
In mammalian cells, cyclin D and E form active complexes with CDKs in order to promote cell proliferation.
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