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Rheb in its active form activates mammalian target of rapamycin complex 1 (mTORC1), a key regulator of protein translation, metabolism and cell proliferation.
Pro-caspases are cleaved and the cleaved form activates apoptotic signal.
In a less extreme case, the fully phosphorylated form activates another kinase which then interacts with the chain.
The Ras proteins cycle between a GDP- and GTP-bound form; only the GTP-bound form activates adenylyl cyclase.
MMP-9 cleaves interleukin-8 to its more potent truncated form, activates IL-1β and transforming growth factor β (Chakrabarti and Patel 2005).
Rho in GTP-bound form activates its effector, Rho-associated serine threonine protein kinase (ROCK), which then induces MLC2 phosphorylation (Kimura et al, 1996; Wilkinson et al, 2005).
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FEIBA (Baxter AG, Vienna, Austria) is unique because it contains factor VII primarily in the activated form (activated PCC (aPCC)) [ 9].
Sphingopyxis sp. PVA3 and Pseudomonas sp. A-41 form activated sludge, also seen for PVA degradation (Agrawal and Shahi 2015; Fukae et al. 1994).
This may indicate that NP-Pt analogs to platinum-based drugs, where Pt exists in cationic form, activate apoptosis and at the same time suppress proliferation.
With one line of code, and in less than a minute, Instabug's bug reporting feature can be added to any application - a feedback form activated by simply shaking the phone.
However, it is not known whether oncogenic EGFRvIII is able to form activating dimers with ERBB3.
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CEO of Professional Science Editing for Scientists @ prosciediting.com