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But first, some justification.
Jonathan Quong has argued (2004, 233 250) that the requirement of public justification applies first and foremost to laws, a more finely grained kind of principle justifying coercion.
John Rawls was the foremost advocate of the idea of public justification, though its importance is also stressed in the works of Jürgen Habermas, David Gauthier, Gerald Gaus, Stephen Macedo, Charles Larmore, Seyla Benhabib and many others.
While uncertainty is related to the quality and quantity of the read across endpoint data, uncertainty also includes a variety of other factors, the foremost of which is uncertainty associated with the justification of similarity and quantity and quality of data for the source chemical(s).
As a Wesleyan, I define grace first and foremost as God's quest to win our trust through Christ's justification on the cross and then make us holy and beautiful through the Holy Spirit's sanctifying transformation.
Though European leaders tried to give sound economic justifications for the merger, the nascent monetary union was first and foremost a political creation, a currency knot meant to bind vastly different states to a common interest.
Humanitarian agencies have several objections to the plan, but foremost among them is the concern that Assad and his allies could use the flight of civilians as justification for an even more indiscriminate campaign against eastern Aleppo, with the argument that those staying behind have chosen to aid "terrorists", the regime's catch-all term for the opposition.
The justification?
First and foremost: Really?
Children first and foremost.
There's your justification.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com