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The foremost challenge is to identify reliable and effective means of characterizing different types of MPs and distinguishing their functional specificities.
In an era of burgeoning demand for higher education, the foremost challenge is to increase the capacity of our public research universities by an order of magnitude.
Although there are numerous drug therapies for the treatment of acne (topical, systemic retinoid, antibiotics, and keratolytics), the foremost challenge is the growing concerns of rising antibiotic resistance and dermal toxicities with existing medications.
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The shortage of clean water possessions is the foremost challenge being faced by the Kingdom of Saudi Arabia (KSA).
Therefore, one of the foremost challenges is to develop highly active, yet inexpensive OER catalysts.
One of the foremost challenges is the design of robust algorithms for representing and matching biometric samples obtained from uncooperative subjects under unconstrained environmental conditions (e.g., recognizing faces in a crowd).
"One of the foremost (challenges) being the development of a robust and scalable business model in new paradigm of the no-entry-load regime.
First and foremost, however, the challenge is in the field.
First and foremost, a major challenge was finding very few unvaccinated children, which limited the study's power to make any conclusions about bias.
But reading their op-ed, one would naturally and wrongly conclude that reducing deficits is the foremost challenge posed by the "fiscal cliff," whereas the challenge is reducing the pace of deficit reduction currently scheduled in order to sustain the recovery.
The battle is fought within each of us: the foremost challenge we face is that posed by our own sinfulness, which is overcome when we acknowledge that control of our destiny lies finally with God, and give up our false claim to ourselves.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com