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We, therefore, hypothesize that in case of p53 downstream targets, the foremost activated positive feedback in a coupled feedback circuit can rapidly induce the "on" state transition of the signaling system (p53 activating downstream target genes), and that then another delayed positive feedback (p53 suppressing miRNAs that target p53 downstream target genes) robustly maintains this "on" state.
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Preschool: activated plane, activated ground.
The activated RhoA activates MAPK.
The reversed contrast, i.e. brain regions that are more activated during fixation compared with task revealed activity in the default mode network (DMN), foremost in its posterior sub-network, including the bilateral posterior parietal cortex and the precuneus/posterior cingulate cortex.
Foremost is debugging.
First and foremost: Really?
Children first and foremost.
Immigration is foremost.
First and foremost, Gonzaga.
They are designers, foremost.
First and foremost is safety.
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