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High-dose daptomycin was compared with standard regimens of oxacillin and vancomycin in a difficult-to-treat rat tissue cage model of chronic S. aureus foreign body infection, so called as perforated Teflon cylinders are implanted subcutaneously in rats, and infected, in this case with MSSA strain I20, a clinical isolate from catheter-related sepsis.
Whole body biodistribution and accumulation of [18F]FDG-6-P athehe sites of bioluminescent staphylococcal infection were established in a murine foreign body infection model.
The AB foreign body infection studies were performed as previously described (Kadurugamuwa et al., 2003).
In a pilot model by Lucet et al, an experimental foreign body infection and therapy was reported.
In a subcutaneous foreign body infection model, daily AZM reduced by > 90% the quantity of MDR- AB recovered after 3d (Fig. 4G).
Řičicová et al. have addressed this issue and developed a rat in vivo C. albicans foreign body infection model in which small pieces of catheter challenged with C. albicans cells are subcutaneously implanted in rats (Řičicová et al., 2010).
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Despite the unexpected whole-body biodistribution of [18F]FDG-6-P in vivo, the accumulation of [18F]FDG-6-P and [18F]FDG at the site of bacterial catheter foreign body infections was characterised.
It causes a wide range of infections including skin and soft tissue (such as impetigo or abscesses), deep bone and foreign body infections that can lead to sepsis and pneumonia [22].
This is an important virulence factor in causing foreign body infections which are more indolent by nature.
According to Kloos and Bannerman [ 10], S. epidermidis and S. haemolyticus are the principal pathogens involved in foreign body infections.
We previously described an animal model for evaluating the in vivo activity of various bactericidal antibiotics against localized chronic foreign body infections due to S. aureus [ 32- 38].
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