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The connection between aneuploidy and disease has been at the forefront of the study of aneuploidy.
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On the clinical side, they've been at the forefront of the studies that have shown that protease inhibitors, a new class of anti-HIV drugs, can drive blood HIV levels down to undetectable levels for more than a year in many patients, when used in combination with older drugs like AZT and 3TC.
The zebrafish model is at the forefront of these studies.
The recent US Food and Drug Administration's approval of bevacizumab has reinvigorated antiangiogenic research and has moved colorectal cancer to the forefront of study for the most promising drug candidates in this class.
Bluetongue virus (BTV) which causes disease in livestock (sheep, goat, cattle) has been in the forefront of molecular studies for the last three decades and now represents the best understood orbivirus at a molecular and structural level.
The blueprints for our human machine reside, or course, in the genome, and accelerating progress in genomic technology, and deciphering the genomic bases of disease risks, has put genetics at the forefront of recent studies in the etiology of polygenic disease.
"This course puts our university at the forefront of studies in this field and confirms the church's desire to be present with the greatest commitment in this area," Bishop Enrico dal Covolo, rector of the university, was quoted by the Catholic News Agency as saying.
The model organism Drosophila melanogaster has been at the forefront of genetic studies since before the discovery of DNA.
The A. socius complex of crickets (including the species A. socius, A. fasciatus, and A. sp. nov. Tex) has been a model system within ecology and evolutionary biology for nearly three decades and has been at the forefront of studies assessing the importance of postmating, prezygotic reproductive isolation [27] [32].
Indeed, yeast has remained at the forefront of studies on the nucleus the defining characteristic of eukaryotes for several decades.
John Stadler, literature graduate student at Duke University, and one of the figures at the forefront of porn studies, explained this to me more fully in an email.
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