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Details of model structure, input parameters and sexual mixing assumptions are provided in the Supplementary information.

Recognition of input parameters and output results.

Simulations demonstrate satisfactory performance of the estimation approach to identify model parameters subject to precise specifications of input parameters and adequate numbers of interval cancers.

Amelia II has several input parameters, and can apply various transformations to the input data.

'Build' collects input parameters and displays model scoring.

Here the relationship between the forecasted parameter and the input parameters are described by an equation of the form: begin{aligned} {{varvec{y}}}={{varvec{x}}}cdot {varvec{beta }} +{varvec{varepsilon }} end{aligned} (3).

Here the relationship between the forecasted parameter and the input parameters are described by an equation of the form: begin{aligned} {{varvec{y}}}={{varvec{x}}}cdot {varvec{beta }} +{varvec{varepsilon }} end{aligned} (3)  where ({{varvec{x}}}) is the input vector, ({varvec{beta }}) is the slope vector and ({varvec{varepsilon }}) the error vector.

It requires two input parameters, Eps and MinPts.

Material properties, physical parameters, and input parameters for simulation.

These values are based on the solution of three equations with three input parameters: δ′18Oshale, δ′17Oshale and the proportion of quartz (see Extended Data Fig. 3).

App cells show the chosen input parameters for the application and the results of the analysis.