Sentence examples for forces differentiation from inspiring English sources

PDGF overexpression forces differentiation of glial cells to the oligodendrocyte lineage and promotes the development of highly malignant oligodendroglial tumors in mice [ 96- 98].

The study argues that the experimental setting of the transplantation assay forces differentiation of basal MaSCs into both epithelial lineages while the intact gland relies on lineage-restricted unipotent stem cells.

Our data showed that forced differentiation of HPV-positive KCs resulted in the expression of TLR9, however, as HPVs inhibits differentiation this may appear as TLR9 loss similar to what was seen previously [12].

Following forced differentiation in culture the limbal epithelial cells revealed an increase in K5/14 gene/protein expression levels in concert with a predictable rise in a known differentiation marker.

Furthermore K14/K5 expression levels were not lowered (in fact they increased) within a limbal epithelial cell culture undergoing forced differentiation suggesting K14/K5 is an unreliable maker for undifferentiated cells ex vivo.

Our hypothesis that Elf5 regulates the switch from mammary epithelial cell proliferation to differentiation is supported by the report of a mouse in which ectopic over-expression of Elf5 in the mammary gland led to a reduction in epithelial proliferation and forced differentiation of the mammary epithelium [19].

ACSVL3 expression was diminished by ∼80% following forced differentiation.

Forced differentiation was also used to sensitize GSC to radiotherapy.

Forced differentiation was performed according to previous published protocol adapted as follows.

One of these approaches is forced differentiation of CSCs combined with targeted therapy [ 10].

Forced differentiation has long been proposed to be a rational method to cure leukemia.