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A tour de force screen by Mann and Alessi and co-workers identified a subset of Rab GTPases as bona fide LRRK2 substrates.
In addition, Cu could act as a driving force screen for the GBM, which indicates that the GBM is partially pinned by the Cu supply.
Modifications to an in vitro chromatin assembly assay are described that allowed a brute force screen of temperature sensitive (ts) yeast strains in order to identify chromatin assembly defective extracts.
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At 08 15, a Yorktown SBD piloted by John L. Nielsen sighted Gotō's force screening the invasion convoy.
Their participation in major and secondary campaigns included the bombardment of beachheads, amphibious landings, task force screening, convoy and patrol duty, and anti-aircraft and submarine warfare.
Vahan deployed Jabalah's Christian Arabs, mounted on horses and camels, as a skirmishing force, screening the main army until its arrival.
It has been of major interest to reduce the amount of brute force screening by PCR genotyping and sequencing of mutations.
Given the number of anticancer agents currently available and the genetic diversity of the disease, the combinatorial explosion of possibilities is beyond what can typically be tested through brute force screening.
Despite of the extensive efforts that have been made to discover new drug combinations in the past few decades, the majority of effective combinatorial drugs used in clinic were discovered through experiences, which generally require labor-intensive and time-consuming "brute force" screening of all possible combinations among the approved individual drugs [ 10].
Channeling the rambunctious spirit of the Puerto Rican playwright, poet and actor Miguel Piñero, whose prison drama "Short Eyes" created a sensation in the early 1970's, Mr. Bratt turns in a tour-de-force screen performance reminiscent of Dustin Hoffman's Lenny Bruce.
Response time histories and frequency response plots assess the model's prediction of wave heights, sloshing forces, and screen forces.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com