This raises a number of ethical issues as many of the principles and procedures in medical research are not designed for wide-scale data sharing.
Such strict new rules would replace a law from 1995, which was conceived as more of a legal directive that effectively limited the possibilities of wide-scale data mining for direct marketing or other commercial purposes.
We developed genomeSIMLA [ 48] for simulating genome-wide scale data in population based case-control samples with a categorical outcome.
The permutation and exhaustive search schemes of the previous GGI methods are computationally too intensive to be employed in large genome-wide scale data set for high-order interactions.
Several ways of accounting for hidden population stratification have been proposed (genomic control (GC) correction, adjusting for ancestry-informative principal components (PCs)), but these approaches are only applicable in genome-wide scale data.
Statistical methods have been developed to infer the fine-scale structure of recombination rate variation from genome-wide scale data [4].
With large genome-wide scale data, this approach makes it feasible to discover higher-order interactions.
The difficulty has been for projects that have been carried out at a time when wide-scale data sharing was not envisaged.
Muchiri summarises the biggest hurdle – the need for wide-scale public awareness.
Most experts consider the current vaccine unsuitable for wide-scale use.
This approach could be generalized for wide-scale applications.
