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Islet donors were genotyped for the 16 CpG-SNPs for which we retrieved DNA methylation data.
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Our search identified 1,482 citations, of which we retrieved 51 citations for more detailed evaluation.
11 12 13 14 15 16 17 In both steps we screened the retrieved abstracts to identify all potentially relevant papers, for which we subsequently retrieved full text publications.
We obtained the same picture for four further TFs for which we could retrieve new, independent data sets.
As a result, there were 118,791 site-days during 2000 for which we can retrieve measured PM10 data and 166,796 site-days for PM2.5 data.
To investigate whether the performance of the PM and PM + CN classifiers is biased by certain clinical features of tumors, we analysed the subset of tumors in our COSMIC-derived training data that originated from TCGA, and for which we could retrieve clinical annotations based on sample names directly from the TCGA repository.
We excluded 1128 postcode sectors for which we could not retrieve census data on ethnic diversity.
Ninety-five studies were identified as potentially relevant, for which we aimed to retrieve full-text articles.
Three central genes, for which we could not retrieve annotations, were only transiently expressed.
In the detailed review of the 300 cases, we excluded redundant cases (n = 5), cases in which target medications were cancelled later (n = 4), and cases for which we could not retrieve the electronic medical records (n = 2).
These studies were men and women from the InCHIANTI study (24) and the cross-sectional studies published in the meta-analysis conducted by Ding et al. (1), for which we were able to retrieve mean and standard deviation measures of SHBG in cases and controls, were restricted to individuals of European ancestry, and had matched or corrected SHBG levels for body mass index or waist circumference.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com